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ILSI North America is committed to sharing the results of the research we support, regardless of the outcomes. Our publications undergo stringent peer-review by qualified experts prior to publication and include disclosure of all sources of funding.

Incorporating New Approach Methodologies in Toxicity Testing and Exposure Assessment for Tiered Risk Assessment Using the RISK21 Approach: Case Studies on Food Contact Chemicals

This study highlights the potential utility of the RISK21 approach for interpretation of the ToxCast HTS data, as well as the challenges involved in integrating in vitro HTS data into safety assessments. This work was supported by the ILSI North America Food and Chemical Safety Committee 2016 Summer Fellowship.

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Evaluating the Applicability of a Risk-based Approach (Decision Tree) to Mycotoxins Mitigation

The primary aim of this work was to evaluate a hypothesis on whether a foundational framework (decision tree) previously developed by the North American Branch of the International Life Sciences Institute (ILSI North America) Food and Chemical Safety Committee for a risk-based approach to mitigation of process-formed compounds could be applied to other not-readily-avoidable substances, such as mycotoxins.

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Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions

ILSI North America previously took on the task of defining a “healthy gut microbiome,” and the outcome of this effort was published by Backhed et al. in 2012. Since that time, the body of work on gut microbiome has grown exponentially. In 2018, >40 invited academic, government, and industry experts gathered to evaluate progress toward this definition and explore the question: Can a Healthy Gut Microbiome be Defined Through Quantifiable Characteristics?

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