The Bioactives Committee seeks to expand the quality of evidence linking health-promoting dietary components with health outcomes and advance translation into dietary guidance by promoting quality research, supporting evidence-based scientific reviews, and partnering with health authorities as they translate science broadly into recommendations for public health benefit.
What are Bioactives? Bioactives are constituents in foods, other than those to meet basic nutritonal needs, that are responsble for a change in human health.
Why is this important?
Science points to the health benefits of food components beyond traditionally accepted “essential” nutrients, yet there is no framework around which to base dietary guidance. It is critical to understand the level of bioactive intake that produces a health effect. The committee is developing guidelines to promote the appropriate methods and terminology when designing and reporting flavonoid research. Harmonization in the literature is critical to building the evidence body needed to support dietary guidance.
COMMITTEE MEMBERS
GSK
Herbalife Nutrition
Ocean Spray Cranberries, Inc.
Ex-Officio: Florida Department of Citrus
ACADEMIC ADVISORS
John Erdman, PhD, University of Illinois
Johanna Dwyer, DSc, RD, Tufts Medical Center
GOVERNMENT LIAISON
Janet Novotny, PhD, US Department of Agriculture
Perspective: Framework For Developing Recommended Intakes Of Bioactive Dietary Substances
Access the bioactives Framework publication and infographic summary here.
This framework is endorsed by ASN.
Projects Supported by the Committee:
Publications
Dietary Intakes of Flavan-3-ols and Cardio-metabolic Health: Systematic Review and Meta-analysis of Randomized Trials and Prospective Cohort Studies
The America Journal of Clinical Nutrition, 2019
Lutein/Zeaxanthin Intake and Visual Outcomes in Adults with Healthy Eyes: Qualitative Gap Analysis
Cogent Medicine, 2019
The purpose of this research was to summarize the data related to lutein/zeaxanthin intake and visual outcomes in adults with healthy eyes using evidence mapping methods and to describe the research to date that would be useful in guiding future research priorities, systematic reviews, and meta-analyses.
The Association Between Macular Pigment Optical Density and Visual Function Outcomes: A Systematic Review and Meta-analysis
Eye - Springer Nature, 2020
A systematic evidence review links the lutein/zeaxanthin-rich macular pigment in retinal eye tissue with visual function. This is an important part of the overall process to quantify recommended intakes of the lutein/zeaxanthin for good health among the general public.
Perspective: Framework for Developing Recommended Intakes of Bioactive Dietary Substances
Advances in Nutrition, 2021
This article describes a framework to develop guidance based on quality evidence fully vetted for efficacy and safety by qualified experts, and designed to communicate the amounts of specific dietary bioactive compounds with identified health benefits.
The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis
Advances in Nutrition, 2021
Increased intake of carotenoids like lutein/zeaxanthin can help with maintaining eye health.
Events
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