This project proposes the development of a framework to facilitate the risk assessment of potential human dietary carcinogens. Such a framework will consider the relevance and inter-species extrapolation of exposure, toxicokinetics, as well as the toxicological mechanisms of action underlying observed tumors. In the case of compounds that exert carcinogenicity via a genotoxic mode of action, the framework should include decision criteria that elucidate circumstances when it is appropriate to assume the default approach of non-threshold, and when it is not appropriate.

This project aims to improve risk assessment of potential human dietary carcinogens by categorizing potential exposure and mode of action scenarios leading to a carcinogenic response, followed by development of an evidence-based risk framework based on specific examples. A framework that encompasses all types of exposure and modes of action would be too broad in scope. Therefore, it is proposed that first, the categorization of potential exposure and mode of action scenarios leading to a carcinogenic response is conducted. This would then be followed by the development of a framework based on sectoral examples such as hepatically activated electrophiles that are potential genotoxic carcinogens.

Proposals are due April 15, 2020

Access the full Request for Proposals

This work is supported by the ILSI North America Food and Chemical Safety Committee

Pre-Proposals Being Accepted on One or Both Topics by Midnight, ET April 20, 2020.

Topic 1: Associations between essential amino acids and functional health outcomes in older adults.

Topic 2: Essential amino acid intakes by diet pattern in older adults in North America.

Pre-Proposals are due April 20, 2020 at Midnight, Eastern Time.

Read the Pre-Proposal.

Access the Pre-Proposal Template.

This project is supported by the ILSI North America Protein Committee