Given the relationship between intake of low-calorie sweeteners (LCS) and diabetes identified in some observational studies, the Committee wishes to support a systematic review of evidence from studies investigating the relationship between LCS and glycemic response and/or glycemic control. An effect on glycemic response is of interest because this is associated with the risk of diabetes. The objective of the proposed systematic review is to identify the strength of the evidence specifically from randomized controlled trials conducted in adults. If this review finds enough evidence to allow a quantitative evaluation with meta-analyses, a follow-up project will be considered.

Submit proposal by 10 December 2019.

View the full Request for Proposals.

This RFP is supported by the ILSI North America Low-Calorie Sweeteners Committee.