Systematic Review Now Available:
Systematic Review of the Potential Adverse Effects of Caffeine Consumption in Healthy Adults, Pregnant Women, Adolescents, and Children.
Selected as the “Best Paper of the Year” for 2017 by the editors of Food and Chemical Toxicology. Learn more.
Why is this research valuable?
The Committee conducted a systematic evidence-based review of the health effects associated with the consumption of caffeine in humans to update the 2003 Nawrot et al. review. Since this time, more than 10,000 papers have been published related to caffeine—approximately 5,000 of such address effects or exposure in humans. It is critical that this new body of literature be evaluated to reflect the current state of the science. The systematic review followed the Institute of Medicine (IOM) Framework, “Finding What Works in Health Care—Standards for Systematic Reviews.” An independent scientific advisory board was formed to undertake this work. The review looked specifically at adverse health outcomes related to caffeine, general toxicity, physiological effects, cardiovascular, bone and calcium, behavior, and reproductive and developmental endpoints and pharmacokinetics. Individual protocols for the review of each of these endpoints has been published on the PROSPERO registration for systematic reviews. Each protocol can be found by following the link for each of the endpoints:
Experimental Biology 2017
This work was presented at Experimental Biology 2017, in Chicago on 22 April.
Applied Food Sciences, Inc.
The Coca-Cola Company
Keurig Dr Pepper
Kraft Heinz Company
Red Bull GmbH
Marilyn Cornelis, PhD, Northwestern University Feinberg School of Medicine
Harris Lieberman, PhD, Military Nutrition Division
U.S. Army Research Institute of Environmental Medicine (USARIEM)
Projects Supported by the Committee:
This Systematic Review looked at five adverse health outcomes associated with caffeine consumption and over 2 dozen specific endpoints related to caffeine in the areas of: acute toxicity, cardiovascular effects, bone and calcium, behavior reproductive & development toxicity.
Panelists’ during ILSI North America’s 2015 Annual Meeting covered topics ranging from the natural occurrence of caffeine in plants and interindividual metabolism of caffeine in humans to specific behavioral, reproductive, and cardiovascular effects related to caffeine consumption.
The objective of this study was to compare two methods of assigning caffeine values to beverages: brand-specific values versus an aggregate single value representing a broader range of products within a beverage category (i.e., category-specific).
This study estimated the caffeine intakes of the U.S. population using a comprehensive beverage survey, the Kantar Worldpanel Beverage Consumption Panel.
This presentation will showcase the recently completed Systematic Review of Caffeine and adverse health outcomes.
ILSI North America is supporting various sessions at the 2017 Experimental Biology Conference.
ILSI North America presented a session on “The Role of Systematic Review in Toxicology—The Rigor, Resources, and Tools Required, and Implementation Considerations for the Toxicology Community.”
This workshop featured presentations on the ongoing Systematic Review on caffeine being done by ILSI North America.
- Harris Lieberman, US Army – Behavior - Video
- Charles O’Brien, University of Pennsylvania – Behavior - Video (See Lieberman for pdf)
- Jennifer Peck, PhD University of Oklahoma – Reproductive & Developmental Toxicity - Video
- Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine– Cardiovascular - Video
- Connie Weaver, PhD, Purdue University – Bone & Calcium - Video
- Milton Tenenbein, MD, University of Manitoba – Acute & Pharmacokinetics - Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of ILSI North America (Oversight Committee) Overall Conclusions - presented by Daniele Wikoff
Full session playlist
This session is supported by the ILSI North America Caffeine Committee. Learn more about this Systematic Review on the Caffeine Committee's webpage.
See ILSI North America's other sessions at Experimental Biology 2017:Full Schedule
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The events below were organized by ILSI North America. To access the entire conference program, visit the Experimental Biology website.
Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine
Saturday, 22 April 2017
8:30AM – 12:30PM
Speakers: Dennis Keefe, FDA; Harris Lieberman, USARIEM; Esther Myers, EF Myers Consulting; Charles O’Brien, University of Pennsylvania; Jennifer Peck, University of Oklahoma; Milton Tenenbein, University of Manitoba; Connie Weaver, Purdue University; Daniele Wikoff, ToxStrategies
Supported by the ILSI North America Caffeine Working Group
Session Info & Videos
The Changing Brain: How Brain Plasticity, Exercise and Nutrition Affect Function and Cognition
Saturday, 22 April 2017
3:00PM – 5:00PM,
- Neurogensis and brain plasticity in the adult brain - Henriette van Praag, National Institute on Aging;
- The Relation of Exercise, fitness, & Adiposity to Cognitive and Brain Health - Charles Hillman, University of Illinois - Video
- Neuroinflammatory Processes in Cognitive Disorders - Sophie Laye, Universite Bordeaux - Video
- Exercise, Nutrition and Brain Funciton: What are the steps toward dietary and physical activity Recommendations? - Mary Ann Johnson, University of Georgia - Video
- Panel Discussion - Video
With Programmatic input from ILSI North America
Utility of Predictive Modeling for Nutrition Research, Clinical Interventions and Public Health
Sunday, 23 April 2017
- Intro to Predictive Modeling: From Linear Regression Models to Mechanistic Mathematical Modeling - David Allison, University of Alabama at Birmingham - Video;
- Use of Predictive Modeling in the Design of Clinical Studies Kevin Hall, NIDDK - Video;
- Application of Predictive Modeling in Weight Loss Counseling - Corby Martin, Pennington Biomedical Research Center - Video;
- Application of Predictive Modeling in Personalized Nutrition - Ben van Ommen, TNO - Video;
- Utility of PRedictive Modeling for Public Health Obesity Policies - Emily Dhurandhar, Texas Tech University - Video;
- Summary and Wrap-Up - Diana Thomas, West Point - Video
Supported by the ILSI North America Protein Committee
- Full session playlist
Learning Lab: How to Access and Use a Fiber and Health Outcomes Database for Researchers and Policymakers
Tuesday, 25 April 2017
11:00AM – 12:30PM
Speakers: Kara Livingston, Tufts University; Caleigh Sawicki, Tufts University
Supported by the ILSI North America Carbohydrate Committee
Sources of dietary folate/folic acid in women of different races in the United States between 2009 and 2012: What is the role of fortified and enriched products?
Abstract Number: 6707
Poster Board Number C88
Presenter: Ray DeVirgiliis, George Washington University
Monday, 24 April