Food-Relevant Chemicals in ToxCast and Potential Integration of High-Throughput Toxicity Testing in Assessing Chemical Safety

Washington, D.C., USA
July 28, 2016 – June 28, 2016
1:00 pm – 2:00 pm


Identification of a Comprehensive Inventory of Feed-Relevant Chemicals and their Effects in the ToxCast High-Throughput Screening Program
Agnes Karmaus, Integrate Laboratory Systems, Inc.

Agenda Curation of food related ToxCast chemical database using exposure groupings to identify current relevance
Lori Fix, ILSI North America Member Scientist

Assessing Bioactivty-Exposure Profiles of Fruit and Vegetable Juices
Barbara Wetmore, US EPA

Webinar Recording

Background: The field of toxicology is undergoing a global paradigm shift in how chemical hazards can be evaluated. There are tens of thousands of chemicals in use, many of which have little to no hazard information, and there are limited resources for testing these chemicals. Advances in molecular and cellular biology, testing technologies and computational toxicology have paved the way for animal-free (in vitro) high-throughput screening (HTS) that can characterize chemical interactions with highly specific biological processes. In the world of food safety, progress has been made in improving safety testing methods focused on microbial contaminants. However, there is a need to move the safety assessment of food-related chemicals such pesticides, direct and indirect additives into next generation approaches. The broad landscape of food-relevant chemical diversity and assay endpoints in ToxCast enables a multitude of analyses for the toxicological identification of specific chemicals of interest. This webinar will provide a forum for integration of scientific disciplines such as food safety, emerging technologies with toxicology; and it will serve as an educational resource to communicate the impact and relevance of food safety and toxicology research with scientists in government, academia and industry.