Evaluating the Applicability of Read-Across Tools and High-Throughput Screening Data for Food Relevant Chemicals

The IAFNS Food and Chemical Safety Committee invests in the training and education of future scientists and leaders in the fields of food and chemical safety and food toxicology by supporting a Summer Fellowship Program for doctoral students. This project focused on Evaluating the Applicability of Read-Across Tools and High-Throughput Screening Data for Food Relevant Chemicals.

Institution: University of Wisconsin Madison
Summer Fellow: Jalissa Wynder, PhD
Year Awarded: 2017

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Comparison and Analysis of Toxcast Data with In Vivo Data for Food-Relevant Compounds Using The Risk21 Approach

The IAFNS Food and Chemical Safety Committee invests in the training and education of future scientists and leaders in the fields of food and chemical safety and food toxicology by supporting a Summer Fellowship Program for doctoral students. This project focused on Comparison and Analysis of Toxcast Data with In Vivo Data for Food-Relevant Compounds Using The Risk21 Approach.

Institution: Michigan State University
Summer Fellow: Alex Turley, PhD
Year Awarded: 2016

Read more: Incorporating New Approach Methodologies in Toxicity Testing and Exposure Assessment for Tiered Risk Assessment Using the RISK21 Approach: Case Studies on Food Contact Chemicals

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Evaluation of Arsenic-Induced Intracytoplasmic Inclusions

Intracytoplasmic inclusions have been observed in various cell types in individuals exposed to high levels of inorganic arsenic in the drinking water or diet and have been classified as micronuclei. However, in our laboratory, we have observed identical types of inclusions in mice exposed to arsenicals and in patients treated with arsenic trioxide for promyelocytic leukemia, and have conclusively demonstrated that these are not micronuclei using electron microscopy and staining with DAPI, a chromosome specific stain. Similar to what has been reported in the literature as micronuclei in the epidemiology studies, the inclusions we observed stain positive with Giemsa, but this is a very non-specific stain. The purpose of this study is to obtain cells from individuals in epidemiology studies that have been exposed to high levels of inorganic arsenic in the drinking water and/or diet and to examine them in detail to determine whether they represent true micronuclei or if they are what we have identified as intracytoplasmic inclusions.

Institution: University of Nebraska Medical Center
Principal Investigator: Samuel Cohen, PhD
Years Awarded: 2014

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Evaluating the Association between Dietary Exposure to Inorganic Arsenic on Health Outcomes for the US Population

Chronic adverse health effects have been observed with exposure to high levels of inorganic arsenic. The health effects related to lower levels inorganic arsenic exposure have not been established. The aim of this study is to evaluate longitudinal cohort studies for their utility in estimating dietary
inorganic arsenic exposure and quantifying statistically reliable associations with health outcomes.

Institution: Exponent
Principal Investigator: Joyce Tsuji, PhD, DABT
Year Awarded: 2014

Read more.

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An Approach to Standardize the Concepts of Low Dose and Nonmonotonic Dose Response in Toxicological Research and Regulatory Science

The IAFNS Food and Chemical Safety Committee invests in the training and education of future scientists and leaders in the fields of food and chemical safety and food toxicology by supporting a Summer Fellowship Program for doctoral students. This project focused on An Approach to Standardize the Concepts of Low Dose and Nonmonotonic Dose Response in Toxicological Research and Regulatory Science.

Institution: New York University
Summer Fellow: Joshua Vaughan, PhD
Amount Awarded: Summer fellows receive a stipend intended to cover living expenses and transportation to/from Washington, DC.
Year Awarded: 2014

Learn more about the IAFNS Food and Chemical Safety Committee.

Toxicology and Risk Assessment of Chemical Mixtures

The IAFNS Food and Chemical Safety Committee invests in the training and education of future scientists and leaders in the fields of food and chemical safety and food toxicology by supporting a Summer Fellowship Program for doctoral students. This project focused on Toxicology and Risk Assessment of Chemical Mixtures.

Institution: University of Cincinnati
Summer Fellow: Mansi Krishan, PhD
Year Awarded: 2013

Learn more about the IAFNS Food and Chemical Safety Committee.

Evaluation of Food-Relevant Chemicals in ToxCast Phase II

The IAFNS Food and Chemical Safety Committee invests in the training and education of future scientists and leaders in the fields of food and chemical safety and food toxicology by supporting a Summer Fellowship Program for doctoral students. This project focused on the Evaluation of Food-Relevant Chemicals in ToxCast Phase II.

Institution: Michigan State University
Summer Fellow: Agnes Karmaus, PhD
Year Awarded: 2012

Read more: Evaluation of Food-Relevant Chemicals in the ToxCast High-Throughput Screening Program

Learn more about the IAFNS Food and Chemical Safety Committee.