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The Caffeine Working Group promotes scientific evaluation of health and safety issues related to caffeine consumption and serves as a resource for reliable science on caffeine to support the advancement of public health.

Systematic Review Now Available

"Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children"

Experimental Biology 2017 Symposium
22 April - Chicago, IL

 

Why is this research valuable?

The Working Group is conducting a systematic evidence-based review of the health effects associated with the consumption of caffeine in humans to update the 2003 Nawrot et al. review. Since this time, more than 10,000 papers have been published related to caffeine—approximately 5,000 of such address effects or exposure in humans. It is critical that this new body of literature be evaluated to reflect the current state of the science. The systematic review will follow the Institute of Medicine (IOM) Framework, “Finding What Works in Health Care—Standards for Systematic Reviews.” An independent scientific advisory board has been formed to undertake this work. The review will specifically look at adverse health outcomes related to caffeine, general toxicity, physiological effects, cardiovascular, bone and calcium, behavior, and reproductive and developmental endpoints and pharmacokinetics. Individual protocols for the review of each of these endpoints has been published on the PROSPERO registration for systematic reviews.  Each protocol can be found by following the link for each of the endpoints:

Experimental Biology 2017
This work was presented at Experimental Biology 2017, in Chicago on 22 April. 

EB2017_4color

COMMITTEE MEMBERS
Applied Food Sciences, Inc.
The Coca-Cola Company
Dr. Pepper Snapple Group
Kraft Heinz Company
Mars, Incorporated
Monster Energy Company
PepsiCo, Inc.
Red Bull GmbH
Starbucks Coffee Company

SCIENTIFIC ADVISORS
Jennifer Peck, PhD
University of Oklahoma Health Sciences Center

GOVERNMENT ADVISOR
Harris Lieberman, PhD
Military Nutrition Division
U.S. Army Research Institute of Environmental Medicine (USARIEM)

Publications

Caffeine: Friend or Foe?

Panelists’ during ILSI North America’s 2015 Annual Meeting covered topics ranging from the natural occurrence of caffeine in plants and interindividual metabolism of caffeine in humans to specific behavioral, reproductive, and cardiovascular effects related to caffeine consumption.

Read more

Beverage Caffeine Intakes in the U.S.

This study estimated the caffeine intakes of the U.S. population using a comprehensive beverage survey, the Kantar Worldpanel Beverage Consumption Panel.

Read more

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Past Events

Experimental Biology 2017

Chicago, Illinois, USA

ILSI North America is supporting various sessions at the 2017 Experimental Biology Conference.

Read more

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							Official Program
					
			About this session
		

While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews”, as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., “Effects of caffeine on human health”, there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos

8:00 – 8:30 Breakfast

Welcome
Alison Kretser, MS, RD, ILSI North America

The Caffeine Landscape – framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video PDF

Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video PDF

The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video PDF

Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 – 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video PDF

Results of Specific Health Endpoints– Scientific Advisory Board Members

  • Harris Lieberman, US Army – Behavior - Video PDF
  • Charles O’Brien, University of Pennsylvania – Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma – Reproductive & Developmental Toxicity - Video PDF
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine– Cardiovascular - Video PDF
  • Connie Weaver, PhD, Purdue University – Bone & Calcium - Video PDF
  • Milton Tenenbein, MD, University of Manitoba – Acute & Pharmacokinetics - Video PDF

Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of ILSI North America (Oversight Committee)

Overall Conclusions - presented by Daniele Wikoff PDF
Full session playlist 

Supplementary files

Additional resources will be posted here closer to the date of the session.

CoffeeBambooSmall

This session is supported by the ILSI North America Caffeine Working Group.  Learn more about this Systematic Review on the Caffeine Working Group webpage. 

Don't miss ILSI North America's other sessions at Experimental Biology 2017!

Full Schedule

The Systematic Review is now available

Download the SR [post_title] => Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => experimental-biology-2017-2 [to_ping] => [pinged] => [post_modified] => 2017-05-24 14:22:38 [post_modified_gmt] => 2017-05-24 14:22:38 [post_content_filtered] => [post_parent] => 0 [guid] => http://ilsina.org/?post_type=event&p=2388 [menu_order] => 0 [post_type] => event [post_mime_type] => [comment_count] => 0 [filter] => raw ) [1] => WP_Post Object ( [ID] => 2386 [post_author] => 14 [post_date] => 2017-03-24 17:02:46 [post_date_gmt] => 2017-03-24 17:02:46 [post_content] => EspressoCropped3 dreamstime_xl_35356661 pencilChart1500 SmallerBreadGrain Fort2smaller

The events below were organized by ILSI North America.  To access the entire conference program, visit the Experimental Biology website.

Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine
Saturday, 22 April 2017
8:30AM – 12:30PM
Ballroom S100BC
Speakers: Dennis Keefe, FDA; Harris Lieberman, USARIEM; Esther Myers, EF Myers Consulting; Charles O’Brien, University of Pennsylvania; Jennifer Peck, University of Oklahoma; Milton Tenenbein, University of Manitoba; Connie Weaver, Purdue University; Daniele Wikoff, ToxStrategies
Supported by the ILSI North America Caffeine Working Group
Session Info & Videos

The Changing Brain: How Brain Plasticity, Exercise and Nutrition Affect Function and Cognition
Saturday, 22 April 2017
3:00PM – 5:00PM,
Ballroom S100BC

  • Neurogensis and brain plasticity in the adult brain - Henriette van Praag, National Institute on Aging;
  • The Relation of Exercise, fitness, & Adiposity to Cognitive and Brain Health - Charles Hillman, University of Illinois - Video
  • Neuroinflammatory Processes in Cognitive Disorders - Sophie Laye, Universite Bordeaux - Video
  • Exercise, Nutrition and Brain Funciton: What are the steps toward dietary and physical activity Recommendations? - Mary Ann Johnson, University of Georgia - Video
  • Panel Discussion - Video

With Programmatic input from ILSI North America

Utility of Predictive Modeling for Nutrition Research, Clinical Interventions and Public Health
Sunday, 23 April 2017
8:30AM– 10:30AM
S105BCD
Speakers:

  • Intro to Predictive Modeling: From Linear Regression Models to Mechanistic Mathematical Modeling - David Allison, University of Alabama at Birmingham - Video;
  • Use of Predictive Modeling in the Design of Clinical Studies Kevin Hall, NIDDK - Video;
  • Application of Predictive Modeling in Weight Loss Counseling -  Corby Martin, Pennington Biomedical Research Center - Video;
  • Application of Predictive Modeling in Personalized Nutrition - Ben van Ommen, TNO - Video;
  • Utility of PRedictive Modeling for Public Health Obesity Policies - Emily Dhurandhar, Texas Tech University - Video;
  • Summary and Wrap-Up - Diana Thomas, West Point - Video
    Supported by the ILSI North America Protein Committee
  • Full session playlist

Learning Lab: How to Access and Use a Fiber and Health Outcomes Database for Researchers and Policymakers
Tuesday, 25 April 2017
11:00AM – 12:30PM
S105AB
Speakers: Kara Livingston, Tufts University; Caleigh Sawicki, Tufts University
Supported by the ILSI North America Carbohydrate Committee

Posters
Sources of dietary folate/folic acid in women of different races in the United States between 2009 and 2012: What is the role of fortified and enriched products?
PDF
Abstract Number: 6707
Poster Board Number C88
Presenter: Ray DeVirgiliis, George Washington University
Monday, 24 April
1:45PM-2:45PM

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While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews”, as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., “Effects of caffeine on human health”, there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos

8:00 – 8:30 Breakfast

Welcome
Alison Kretser, MS, RD, ILSI North America

The Caffeine Landscape – framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video PDF

Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video PDF

The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video PDF

Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 – 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video PDF

Results of Specific Health Endpoints– Scientific Advisory Board Members

  • Harris Lieberman, US Army – Behavior - Video PDF
  • Charles O’Brien, University of Pennsylvania – Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma – Reproductive & Developmental Toxicity - Video PDF
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine– Cardiovascular - Video PDF
  • Connie Weaver, PhD, Purdue University – Bone & Calcium - Video PDF
  • Milton Tenenbein, MD, University of Manitoba – Acute & Pharmacokinetics - Video PDF

Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of ILSI North America (Oversight Committee)

Overall Conclusions - presented by Daniele Wikoff PDF
Full session playlist 

Supplementary files

Additional resources will be posted here closer to the date of the session.

CoffeeBambooSmall

This session is supported by the ILSI North America Caffeine Working Group.  Learn more about this Systematic Review on the Caffeine Working Group webpage. 

Don't miss ILSI North America's other sessions at Experimental Biology 2017!

Full Schedule

The Systematic Review is now available

Download the SR [post_title] => Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => experimental-biology-2017-2 [to_ping] => [pinged] => [post_modified] => 2017-05-24 14:22:38 [post_modified_gmt] => 2017-05-24 14:22:38 [post_content_filtered] => [post_parent] => 0 [guid] => http://ilsina.org/?post_type=event&p=2388 [menu_order] => 0 [post_type] => event [post_mime_type] => [comment_count] => 0 [filter] => raw ) [comment_count] => 0 [current_comment] => -1 [found_posts] => 6 [max_num_pages] => 2 [max_num_comment_pages] => 0 [is_single] => [is_preview] => [is_page] => [is_archive] => 1 [is_date] => [is_year] => [is_month] => [is_day] => [is_time] => [is_author] => [is_category] => [is_tag] => 1 [is_tax] => [is_search] => [is_feed] => [is_comment_feed] => [is_trackback] => [is_home] => [is_404] => [is_embed] => [is_paged] => [is_admin] => [is_attachment] => [is_singular] => [is_robots] => [is_posts_page] => [is_post_type_archive] => [query_vars_hash:WP_Query:private] => dfe3496b8728f1d8b66db58e344d86a3 [query_vars_changed:WP_Query:private] => [thumbnails_cached] => [stopwords:WP_Query:private] => [compat_fields:WP_Query:private] => Array ( [0] => query_vars_hash [1] => query_vars_changed ) [compat_methods:WP_Query:private] => Array ( [0] => init_query_flags [1] => parse_tax_query ) )