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ILSI North America Caffeine Systematic Review was Awarded the 2017 "Best Paper of the Year"

ILSI North America is pleased to announce that its Caffeine Systematic Review has been selected as the “Best Paper of the Year” for 2017 by the journal Food and Chemical Toxicology. This study is a robust and systematic assessment of health outcomes related to caffeine consumption. It was the first study of this kind to be conducted with complete transparency; the research was structured to meet the gold standards for Systematic Reviews outlined by the National Academies of Science Institute of Medicine, and all data and assessment protocols used for the study were deposited into publicly available repositories. This level of complete transparency allows the research community to learn from and build upon this work in the future.

The manuscript, titled “Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children” examined the health effects associated with caffeine consumption in five topic areas: acute toxicity, cardiovascular effects, bone and calcium, behavior, and reproductive and development toxicity. It confirms previous findings that consuming ≤400 mg/day of caffeine (about 4 cups of coffee) is not associated with adverse health outcomes in healthy adults. In addition, the review found no adverse health effects associated with consumption of caffeine in healthy pregnant women (≤300 mg/day) and children (≤2.5 mg/kg-day).

Visit the Caffeine Systematic Review Resource Page to learn more about the study. To learn more about the work of the ILSI North America Caffeine Committee, visit the ILSI North America Caffeine Committee webpage.

Read the Full Manuscript here.

Watch the Caffeine Systematic Review Session at Experimental Biology here.

Wikoff D, Welsh BT, Henderson R, Brorby GP, Britt J, Myers E t al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol. 2017 Nov;109(Pt 1):585-648. doi: 10.1016/j.fct.2017.04.002.

Finalists Announced for NUTRITION 2018 Dietary Bioactives Research Design Challenge

ILSI North America is challenging the next generation of nutrition scientists to find innovative ways to include safety measures in nutrition research. Non-essential bioactive dietary components hold promise for helping maintain optimal health and reducing risk of chronic disease, yet most efficacy studies are not sufficiently designed or powered to measure their safety. In the ILSI North America Research Design Challenge at NUTRITION 2018, interdisciplinary teams pitched novel research designs that integrate safety measures and primary efficacy measures into a single study. Data obtained from such studies will improve the confidence of regulatory bodies with product oversight and health professionals providing advice to the general public.

First place was awarded to Team Rutgers, led by Alexandra Kreitman, Department of Nutritional Sciences, for their research design titled “Measuring Safety and Efficacy of a Health Promoting Dietary Component: Monitoring GI side effects of a putative α-glucosidase inhibitor.”

Second place was awarded to Team University of Alabama, Birmingham, led by Yuanyuan Rose Li, Department of Pharmacology and Toxicology, for their research design titled “An effective method to balance efficacy and safety test for bioactive soybean isoflavone-enhanced chemotherapy in breast cancer patients.”

Videos of the “Shark Tank”-style presentations can be viewed here.

Design challenge judges were Paul Coates, Office of Dietary Supplements; James Coughlin, Coughlin & Associates; and Christina Khoo, Ocean Spray Cranberries. Research teams were mentored by Jiang Hu, Herbalife; and Tia Rains, Ajinomoto Health & Nutrition North America, Inc.

The Bioactives Research Design Challenge was supported by the ILSI North America Bioactives Committee. Learn more about the Research Design Challenge here.

Best Practices for Measuring and Reporting Blood Fatty Acids in Clinical Nutrition Studies

ILSI North America strives to improve best practices in food and nutrition research. An expert writing group convened by the ILSI North America Dietary Lipids Committee has developed a checklist of recommendations to facilitate the design, review, and evaluation of fatty acid studies with the intention of improving study reproducibility. These recommendations address factors that hinder translating fatty acid research into dietary guidance, including the lack of consistent methodology and reporting of circulating omega-3 fatty acids.

These best practices were vetted by a global panel of experts and presented at a National Institutes of Health mini-symposium before being finalized. The guidelines and checklist have been published in the American Journal of Clinical Nutrition, and sessions were completed at the Canadian Nutrition Society (CNS), the International Society for the Study of Fatty Acids (ISSFAL) and NUTRITION 2018, which draw an international audience of research experts.

Watch the videos of this scientific session at NUTRITION 2018.

Read the full publication.

Learn more about the work of the ILSI North America Dietary Lipids Committee.

Videos from the Canadian Nutrition Society “Food for Health” workshop are now available!

ILSI North America’s collaborations with the Canadian Nutrition Society were highlighted in the 8th annual Food for Health workshop. Videos of all presentations from the workshop are now available on ILSI Global’s YouTube channel.

The workshop, “The Canadian Diet: An Opportunity for Improved Health via our Food System”, explored what a Canadian diet could and should look like, linkages between health and agriculture, and balancing personalized nutrition and dietary patterns in nutrition guidance. The workshop featured speakers from universities (four), government (two) and industry (one), was attended by over 125 academic, government, industry and health professional experts.

The workshop took place on Thursday, May 3rd, 2018 in Halifax, Nova Scotia, Canada. The day concluded with two interactive activities: 1) discussion groups addressing elements to include in future food and health policy in Canada and what a Canadian diet should include, and 2) the generation of a word cloud encompassing the key elements of the Canadian Diet. A report and publication from the workshop are currently being developed.

View all presentations from the workshop on ILSI Global’s YouTube channel.

Did you know? "Gut on a chip" may give insights on the gut microbiome and motility disorders

The ILSI North America 2017-2019 Trends Reporthighlights how new technologies are reshaping our approach to human health and life science research. Organs-on-chips and future human chip networks may offer better insight into how pathogens, chemical toxicants, bioactives and nutrients impact health and disease outcomes. Read more here.

The NIH National Center for Advancing Translational Sciences (NCATS), in collaboration with other NIH centers, the Food and Drug Administration (FDA) and the Defense Advanced Research Projects Agency (DARPA), is leading the Tissue Chip for Drug Screening program. The goal of this program is to develop human tissue chips that accurately model the structure and function of human organs, including the gastrointestinal system, lung, liver and heart. While this program is currently focused on toxicity testing, plans are underway to renew the program with a focus on disease modeling and efficacy testing. Chips of human intestinal tissue containing smooth muscle and nerves may be used to study the gut microbiome, screen for gut motility diseases and monitor drug absorption.

Learn more about this new technology in the 2017-2019 Science Trend Report.

Short on time? Get fast facts from the 2017-2019 Emerging Science Brief.