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Experimental Biology 2017

Chicago, Illinois, USA

ILSI North America is supporting various sessions at the 2017 Experimental Biology Conference.

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Speakers:
Nancy Bontemp, PhD, Mondelez International
Delia Murphy, ILSI North America

Background:
This presentation will provide an overview of the results of two ILSI North America sponsored research projects: “Correlation of surrogate bacteria and Salmonellae for validation of spice/herb pathogen reduction processes” and “Protocol and surrogate validation for the inactivation of Salmonella on whole black peppercorns and cumin seeds.”

The projects used four spices, oregano, onion powder, whole black peppercorns, and whole cumin seeds, and focused on evaluating the usefulness of surrogate bacteria for validation of irradiation as a decontamination processes, and developing validated protocols for inactivation of Salmonella using ethylene oxide fumigation and dry steam (vacuum-assisted) treatment. The American Spice Trade Association provided an unrestricted grant to help fund these research projects.

This work is supported by the ILSI North America Food Microbiology Committee.

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While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews”, as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., “Effects of caffeine on human health”, there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda

8:00 – 8:30 Breakfast

Welcome
Alison Kretser, MS, RD, ILSI North America

The Caffeine Landscape – framing the need for the Systematic Review
Dennis Keefe, PhD, FDA

Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting

The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies

Q&A
Moderated by Dennis Keefe, PhD

10:10 – 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies

Results of Specific Health Endpoints– Scientific Advisory Board Members

  • Harris Lieberman, US Army – Behavior
  • Charles O’Brien, University of Pennsylvania – Behavior 
  • Jennifer Peck, PhD University of Oklahoma – Reproductive & Developmental Toxicity 
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine– Cardiovascular
  • Connie Weaver, PhD, Purdue University – Bone & Calcium 
  • Milton Tenenbein, MD, University of Manitoba – Acute & Pharmacokinetics

Panel Discussion with the Caffeine Systematic Review Project Team Members
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of ILSI North America (Oversight Committee)

Supplementary files

Additional resources will be posted here closer to the date of the session.

CoffeeBambooSmall

This session is supported by the ILSI North America Caffeine Working Group.  Learn more about this Systematic Review on the Caffeine Working Group webpage. 

Don't miss ILSI North America's other sessions at Experimental Biology 2017!

Full Schedule

The Systematic Review is now available

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The events below are being organized by ILSI North America.  To access the entire conference program, visit the Experimental Biology website.

Conducting a Systematic Review for a Global Audience: Challenges in Merging Nutrition and Toxicological Evidence for a Safety Assessment of Caffeine
Saturday, 22 April 2017
8:30AM – 12:30PM
Ballroom S100BC
Speakers: Dennis Keefe, FDA; Harris Lieberman, USARIEM; Esther Myers, EF Myers Consulting; Charles O’Brien, University of Pennsylvania; Jennifer Peck, University of Oklahoma; Milton Tenenbein, University of Manitoba; Connie Weaver, Purdue University; Daniele Wikoff, ToxStrategies
Supported by the ILSI North America Caffeine Working Group
Session Agenda & Info

The Changing Brain: How Brain Plasticity, Exercise and Nutrition Affect Function and Cognition
Saturday, 22 April 2017
3:00PM – 5:00PM,
Ballroom S100BC
Speakers: Henriette van Praag, National Institute on Aging; Charles Hillman, University of Illinois; Sophie Laye, Universite Bordeaux; Mary Ann Johnson, University of Georgia
With Programmatic input from ILSI North America

Utility of Predictive Modeling for Nutrition Research, Clinical Interventions and Public Health
Sunday, 23 April 2017
8:30AM– 10:30AM
S105BCD
Speakers: David Allison, University of Alabama at Birmingham; Kevin Hall, NIDDK; Corby Martin, Pennington Biomedical REsearch Center; Ben van Ommen, TNO, Emily Dhurandhar, Texas Tech University; Diana Thomas, West Point
Supported by the ILSI North America Protein Committee

Learning Lab: How to Access and Use a Fiber and Health Outcomes Database for Researchers and Policymakers
Tuesday, 25 April 2017
11:00AM – 12:30PM
S105AB
Speakers: Kara Livingston, Tufts University; Caleigh Sawicki, Tufts University
Supported by the ILSI North America Carbohydrate Committee

Posters
Sources of dietary folate/folic acid in women of different races in the United States between 2009 and 2012: What is the role of fortified and enriched products?
Abstract Number: 6707
Poster Board Number C88
Presenter: Ray DeVirgiliis, George Washington University
Monday, 24 April
1:45PM-2:45PM

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Co-hosted by U.S. Food and Drug Administration, Center for Food Safety & Applied Nutrition (CFSAN) and the ILSI North America Technical Committee on Food & Chemical Safety

This workshop will bring together scientists from government, academia and industry to discuss the advances in testing strategies to reduce animal testing and the need for the development of a standardized approach for use of these alternative methodologies in food safety assessment.

Registration

There is no fee to attend the workshop but, registration is required by Tuesday, February 21. Please register for the workshop using this link: Workshop Registration

Webcast Registration
Register for webcast here: webcast registration
Webcast participants can submit questions online during the event. These will be answered as time allows.

Agenda

8:30-8:40 am: Welcome Suzanne Fitzpatrick, FDA Mansi Krishan, ILSI North America

8:40-8:55am
Introductory Remarks
Dennis Keefe, FDA
Heidi Bialk, ILSI North America Member Scientist

8:55-9:35am
Integrated Testing Strategies in Food Safety
Alan Boobis, Imperial College London [30 mins + 10 mins Q & A]

9:35-10:15am
State of the Science on High Through-Put Screening (HTS): Food Safety Perspective
Nadine Bewry, FDA

10:30-11:10am
Case Studies to Describe the Limitations of Using HTS data in Food Safety Assessment
Rebecca Clewell, ScitoVation

11:10 -11:50am
Identify and Translate Learnings from On-Going Assay Validation Efforts into Standard HTS Testing Practices
Richard Judson, EPA

12:50- 1:30pm
Read Across Approaches: Chemical Structure and Bioactivity Profiling Applicable to Food Safety
Grace Patlewicz, EPA

1:30-2:10pm
FDA Perspective on Read Across Approaches
Tim Adams, FDA

2:10-2:50 pm
Organ on a Chip Technology
Daniel Levner, Emulate

3:05- 4:30pm
Panel Discussion Moderator: Suzanne Fitzpatrick, FDA

Panelists:
All speakers, Thomas Hartung, Johns Hopkins University and Katya Tsaioun, Johns Hopkins University

4:30-4:40pm
Concluding Remarks
Suzanne Fitzpatrick
FDA Mansi Krishan, ILSI North America

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Speakers:
Nancy Bontemp, PhD, Mondelez International
Delia Murphy, ILSI North America

Background:
This presentation will provide an overview of the results of two ILSI North America sponsored research projects: “Correlation of surrogate bacteria and Salmonellae for validation of spice/herb pathogen reduction processes” and “Protocol and surrogate validation for the inactivation of Salmonella on whole black peppercorns and cumin seeds.”

The projects used four spices, oregano, onion powder, whole black peppercorns, and whole cumin seeds, and focused on evaluating the usefulness of surrogate bacteria for validation of irradiation as a decontamination processes, and developing validated protocols for inactivation of Salmonella using ethylene oxide fumigation and dry steam (vacuum-assisted) treatment. The American Spice Trade Association provided an unrestricted grant to help fund these research projects.

This work is supported by the ILSI North America Food Microbiology Committee.

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