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Diet and the Microbiome

Bethesda, MD, USA

This Workshop will help to improve rigor and reproducibility in research on the colonic microbiome and identify important dietary information that should be reported and parameters to consider in study design.

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Speakers:
Nancy Bontempo, PhD, Mondelez International
Delia Murphy, ILSI North America

Background:
This presentation will provide an overview of the results of two ILSI North America sponsored research projects: “Correlation of surrogate bacteria and Salmonellae for validation of spice/herb pathogen reduction processes” and “Protocol and surrogate validation for the inactivation of Salmonella on whole black peppercorns and cumin seeds.”

The projects used four spices, oregano, onion powder, whole black peppercorns, and whole cumin seeds, and focused on evaluating the usefulness of surrogate bacteria for validation of irradiation as a decontamination processes, and developing validated protocols for inactivation of Salmonella using ethylene oxide fumigation and dry steam (vacuum-assisted) treatment. The American Spice Trade Association provided an unrestricted grant to help fund these research projects.

This work is supported by the ILSI North America Food Microbiology Committee.

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While the role of systematic reviews becomes more fully appreciated, the quality of systematic reviews is inconsistent. As the field of systematic reviews evolves, there are an increasing number of frameworks and approaches that can be used to conduct such comprehensive research.  When conducting systematic reviews there are questions about how to: develop a protocol and PICO (Population, Intervention, Comparator, Outcome) questions, execute a search strategy, manage data, grade the literature, evaluate and manage biases, and ensure transparency of the process. This session will address these components by using a large multi-endpoint systematic review of caffeine which followed the framework of the IOM Report "Finding What Works in Health Care: Standards for Systematic Reviews”, as a case study.

There continues to be interest within the scientific community in what is a safe level of caffeine intake and if certain populations should have modified recommendations.  Since the 2003 release of the highly cited and valued review by Nawrot et al., “Effects of caffeine on human health”, there have been more than 5,000 articles on the effects of caffeine in humans published, highlighting the need for an update to this body of work.

The Systematic Review of the effects of caffeine on human health took into account the challenges of including nutrition and toxicological evidence. The health endpoints reviewed for caffeine are: acute toxicity, behavior, bone and calcium homeostasis, cardiovascular health, developmental and reproductive toxicity, and pharmacokinetics in three healthy populations.  The session will present the lessons learned and will emphasize the efforts taken to ensure transparency and rigor that allow for the achievement of a high level of scientific quality.  Specific areas of focus will include challenges with identifying and integrating caffeine intakes by level of adversity (e.g., physiological or clinical endpoints), and difficulties in applying standard risk of bias tools across outcomes and endpoints.

Although this session will focus on the Caffeine Systematic Review as a case study, the process, findings, and lessons are relevant to nutrition researchers and professionals who utilize systematic reviews.

Agenda & Videos

8:00 – 8:30 Breakfast

Welcome
Alison Kretser, MS, RD, ILSI North America

The Caffeine Landscape – framing the need for the Systematic Review 
Dennis Keefe, PhD, FDA
Video PDF

Striving for the Gold Standard in the Systematic Review Process
Esther Myers, PhD, RDN, FAND, EF Myers Consulting
Video PDF

The Methodology and Challenges of the Caffeine Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video PDF

Q&A
Moderated by Dennis Keefe, PhD
Video

10:10 – 10:25 Break

General Results of the Systematic Review
Daniele Wikoff, PhD, ToxStrategies
Video PDF

Results of Specific Health Endpoints– Scientific Advisory Board Members

  • Harris Lieberman, US Army – Behavior - Video PDF
  • Charles O’Brien, University of Pennsylvania – Behavior - Video (See Lieberman for pdf)
  • Jennifer Peck, PhD University of Oklahoma – Reproductive & Developmental Toxicity - Video PDF
  • Daniele Wikoff on behalf of Jeffrey Goldberger, University of Miami, Miller School of Medicine– Cardiovascular - Video PDF
  • Connie Weaver, PhD, Purdue University – Bone & Calcium - Video PDF
  • Milton Tenenbein, MD, University of Manitoba – Acute & Pharmacokinetics - Video PDF

Panel Discussion with the Caffeine Systematic Review Project Team Members Video
Moderated by Dennis Keefe, PhD
Panel includes: 6 of the 7 Scientific Advisory Board members, Daniele Wikoff of ToxStrategies (Scientific Review Team), Alison Kretser of ILSI North America (Oversight Committee)

Overall Conclusions - presented by Daniele Wikoff PDF
Full session playlist 

Supplementary files

Additional resources will be posted here closer to the date of the session.

CoffeeBambooSmall

This session is supported by the ILSI North America Caffeine Working Group.  Learn more about this Systematic Review on the Caffeine Working Group webpage. 

Don't miss ILSI North America's other sessions at Experimental Biology 2017!

Full Schedule

The Systematic Review is now available

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